免疫疗法相关的低炎:叙述性审查
Vincenza Di Stasi1, Domenico La Sala2, Renato Cozzi3
1Center of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroentherology IRCCS Saverio De Bellis, 70013 Castellana Grotte, Italy.
Cancers
|February 13, 2025
概括
免疫检查点抑制剂 (ICI) 可以导致低血清炎,这是一种有害的内分泌副作用. 早期诊断和激素替代治疗对于管理这种情况和保持患者的生活质量至关重要.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
- 与免疫相关的不良事件 (irAEs) 是ICI的一大问题.
- 低血位炎是一种有害的内分泌性irAE,影响垂体腺.
研究的目的:
- 综合当前关于ICI诱导的低体位炎 (IH) 的知识.
- 审查IH的发病,临床特征,诊断和管理.
- 提高IH的认识和指导临床实践.
主要方法:
- 对最近的文献和临床试验进行叙述性审查.
- 深入分析诊断挑战和重叠的症状.
- 综合管理策略,包括激素替代和监测.
主要成果:
- 由于症状与恶性瘤重叠,IH诊断具有挑战性.
- 诊断评估包括临床评估,激素分析和MRI.
- 管理需要多学科的方法,包括激素替代和监测.
结论:
- 早期识别和及时干预对于管理IH至关重要.
- 个性化,多学科的护理对于最佳的患者结果至关重要.
- 有效的管理可以减轻对生活质量的长期影响.
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