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喉癌的临床和病理阶段差异:系统性审查
Giancarlo Pecorari1, Andrea Lorenzi1, Matteo Caria1
1Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy.
Cancers
|February 13, 2025
概括
喉癌 (LSCC) 的临床分期往往与病理分期不匹配,影响治疗. 这次审查突出显著的不准确性,特别是T2和T3瘤的低阶段,影响了患者的结果.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 诊断成像 诊断成像 诊断成像
背景情况:
- 喉平细胞癌 (LSCC) 是一种常见的头癌.
- 准确的分期 (临床TNM与病理TNM) 对于治疗决策至关重要.
- 目前的成像方法在精确确定LSCC程度方面存在局限性.
研究的目的:
- 在LSCC中系统地审查和评估临床和病理阶段之间的一致性.
- 量化分阶段的不准确性,包括低分阶段和超分阶段.
- 确定对LSCC管理和患者结果的影响.
主要方法:
- 在主要的生物医学数据库 (PubMed,Embase,Scopus,Cochrane,Web of Science) 中进行全面的文献搜索.
- 包括具有直接cTNM-pTNM相关性的回顾性案例系列和观察性研究.
- 数据提取和对一致率和分阶段差异的分析.
主要成果:
- 分析了31项涉及7939名患者的研究.
- 总体临床病理阶段一致性为86.43%.
- 在临床T2和T3LSCC中,低阶段是常见的,而T4显示出更高的一致性.
结论:
- 对LSCC的临床分期准确性仍然是一个重大挑战.
- 在检测微妙入侵时的成像限制导致频繁的分期错误.
- 不准确的分期可能会对生理结果产生负面影响,特别是对于器官保存策略.
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