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一个预后症状模型,包括患者报告的多发性骨髓瘤移植不合格患者的症状

Amaris K Balitsky^1,2,3, Rinku Sutradhar^4,5, Hsien Seow^1,2,3,6

¹Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada.

|February 13, 2025

概括

患有移植不合格的多发性髓瘤 (MM) 的患者往往会出现持续的症状. 基线症状严重程度是未来症状负担的最强有力的预测因素,包括疼痛,疲劳和抑郁症.

科学领域:

在瘤学瘤学.
血液学血液学血液学
抚慰性护理是一种缓解性护理.

背景情况:

不符合移植 (TIE) 资格的多发性骨髓瘤 (MM) 患者面临着显著的症状负担.
预测和管理这些症状对于改善患者的生活质量至关重要.

研究的目的:

开发和验证一种预后模型,用于预测TIEMM患者的症状负担.
在一年内确定中度至严重症状的关键预测因素.

主要方法:

在加拿大安大略省对1535名TIEMM患者进行了回顾性队列研究.
使用链接的行政医疗保健数据库和埃德蒙顿症状评估系统 (ESAS) 数据.
开发了一种多变量后勤回归模型,以预测在索引日期后一年内中度至严重的疼痛,疲劳,抑郁和健康状况下降.

主要成果:

基线严重疼痛,疲劳,抑郁和健康状况下降是经历这些症状一年后最强烈的预测因素.
一年后中度至重度症状的几率比率在4.12至28.07之间,根据基线严重程度.
患者的中位年龄为75岁,超过25%的患者年龄为80岁或以上.

结论:

症状负担,包括疼痛,疲劳,抑郁和健康状况下降,在TIE MM患者中持续存在.
基线症状严重程度是这种人群中未来症状负担的最重要的预测指标.
开发的预后模型可以帮助识别具有持续症状高风险的TIE MM患者.

关键词:

多发性骨髓瘤是多发性骨髓瘤的一种.患者报告的结果.症状症状症状症状症状

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