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Updated: May 28, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Published on: September 30, 2016

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通过共同准AXL和SRC来协同抑制耐药KRAS突变非小细胞肺癌

Soumavo Mukherjee1, Dhananjay Suresh1, Ajit Zambre2

  • 1Department of Bioengineering, University of Missouri, Columbia, MO 65211, USA.

Cancers
|February 13, 2025
PubMed
概括

双重抑制AXL和SRC克服了KRAS突变非小细胞肺癌 (NSCLC) 的耐药性. 这种方法针对AXL-SRC-Akt轴,减少KRAS活动并诱导癌细胞死亡.

关键词:
一个AXL一个AXL达沙替尼布 (Dasatinib) 是一种克拉斯 (Kras) 是一个国家.标志SGI-707979 的地方.在SRC中,它是SRC.这里是TKI TKI.药物耐药性 耐药性 药物耐药性

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