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Updated: May 28, 2025

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S-Adenosylmethionine:癌症发病和治疗中的多方面调节剂

David Fernández-Ramos^1,2, Fernando Lopitz-Otsoa¹, Shelly C Lu³

¹Precision Medicine and Metabolism Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.

|February 13, 2025

概括

S-adenosylmethionine (SAMe) 在癌症中至关重要,影响瘤生长和治疗. 调节SAME对癌症诊断,预后和治疗有希望,但需要进一步研究才能临床使用.

科学领域:

生物化学生物化学
在瘤学瘤学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

S-adenosylmethionine (SAMe) 是细胞过程中的重要甲基供体,包括DNA,RNA和蛋白质甲基化.
SAMe影响基因组稳定性,基因表达,细胞平衡,并在癌症病原发生过程中发挥多方面的作用,包括瘤发病,进展和治疗耐药性.
SAMe与聚胺合成和氧化应激管理有关,这突显了它在癌症生物学中的重要性.

研究的目的:

审查SAME在癌症发病过程中的多样性作用.
探索SAME作为诊断和预后生物标记物的潜力.
检查SAME在癌症治疗中的新兴治疗应用.

主要方法:

关于SAME与癌症有关的最新研究的综述.
分析SAME对甲基化模式,氧化应激和聚胺合成的影响.
研究精准医学方法,将SAME与化疗相结合.

主要成果:

SAMe 影响瘤的开始,进展和抵抗.
SAMe显示出作为癌症诊断和预后的生物标志物的潜力.
当SAME补充/调制用于精密医学方法时,可能会增强现有的癌症治疗方法并改善结果.

结论:

SAMe在癌症生物学中发挥着关键作用,并具有有前途的治疗潜力.
准 metionin 循环和探索表体转录体调节 (例如,m6A) 是有前途的治疗策略.
需要进一步的研究来解决诸如生物可用性,患者分层和在广泛临床实施之前在动物模型中临床验证等挑战.

关键词:

这是一种S-adenosylmethionine.生物标志物生物标志物癌症癌症癌症癌症癌症甲基化处理的方法治疗疗法治疗疗法治疗疗法

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