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Updated: May 28, 2025

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通过分子动力学辅助发现了新型固酶-5抑制剂,其向的是一个独特的囊

Weihao Luo1, Runduo Liu2, Xinlin Cai1

  • 1School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, China.

Molecules (Basel, Switzerland)
|February 13, 2025
PubMed
概括

研究人员发现了针对独特口袋的新型固酶-5 (PDE5) 抑制剂. 一种化合物AI-898/12177002对PDE6具有很高的选择性,在勃起功能障碍和肺动脉高血压治疗中可能减少副作用.

关键词:
一个全osteric 的口袋.分子动力学分子动力学基化酶-5的使用选择性的选择性

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