作为具有潜在应用在化品中的多功能分子的新型佐-单类杂交物
Desislava Kirkova1, Yordan Stremski2, Maria Bachvarova2
1Agricultural Academy, Tobacco and Tobacco Products Institute, 4108 Markovo, Bulgaria.
从硫醇和卡瓦克罗尔精油中合成的新型佐-单类杂交物显示出作为多功能化品成分的前景. 这些化合物具有高的SPF值,抗微生物和抗氧化活性,毒性低.
科学领域:
- 药用化学 医学化学
- 化品科学 化品科学
- 自然产品化学 自然产品化学
背景情况:
- 来自*Thymus vulgaris*和*Origanum vulgare*的精油,富含甲醇和卡瓦克罗尔,广泛用于医学,化品和食品.
- 西醇 (BT) 与性单类的分子杂交提供了一条通往新生物活性化合物的途径.
- 像PBSA这样的现有UVB过器在太阳保护的化品配方中至关重要.
研究的目的:
- 通过区域选择性α-amidoalkylation反应合成新的本佐提亚-单类杂交物.
- 评估合成化合物的光谱性质,阳光保护因子 (SPF),抗菌和抗氧化活性.
- 评估这些混合物作为化品应用的多功能成分的潜力.
主要方法:
- 通过区域选择性α-amidoalkylation使用蒂摩尔和卡尔瓦克罗尔合成本佐提亚-单类杂交物.
- 使用NMR (1H, 13C),FT-IR和HRMS进行结构性表征.
- 对光谱特性和SPF的测定进行光谱光度分析;针对抗菌活性进行亚格扩散测定;针对激素清除活性进行ABTS和DPPH测定;针对毒性预测进行in silico分析.
主要成果:
- 由于一种成本效益高且简单的合成方法,可以获得高产量 (70-96%) 的佐-单类混合物.
- 合成的化合物表现出SPF值在31至36之间,与商业UVB过器PBSA (SPF30) 相似或超过.
- 观察到抗微生物活性,特别是针对金黄色葡萄球菌,并且发现了显著的激素清除活性.
结论:
- 合成的西醇-单类混合物是具有增强性能的化品UVB过器的有效结构类型.
- 这些化合物显示出有前途的抗微生物和抗氧化潜力,适合用于化品和食品中的防腐剂和抗氧化剂.
- 在分析表明混合物是非变异性的,具有低毒性,并且不刺激,确定它们是多功能化品成分的有价值的支架.
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