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系统性审查:青春期前除是否降低了狗乳腺瘤的风险?
Phillip Guirguis1, David S Beggs1
1Melbourne Veterinary School, University of Melbourne, 250 Princes Highway, Werribee, VIC 3030, Australia.
Animals : an open access journal from MDPI
|February 13, 2025
概括
狗的早期化 (青春期前) 可能不会降低乳腺瘤的风险. 更新的文献审查表明,保护作用的证据有限,这表明需要进行特定品种的研究来确定最佳化年龄.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 狗的健康 狗的健康
- 手术手术手术手术手术手术手术手术手术手术
背景情况:
- 卵巢切除和卵巢切除 (消毒) 是狗的常见手术程序.
- 绝育的最佳年龄仍在争论中,根据感知乳腺癌风险降低,对青春期前绝育的历史建议仍在争论中.
- 最近的证据质疑了早期割和乳腺瘤发育减少之间的确立联系.
研究的目的:
- 系统地审查最新的文献,以了解狗的消毒年龄与乳腺瘤的发展之间的关系.
- 评估关于早期割和乳腺瘤风险的证据是否自之前的审查以来发生了变化.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 在2023年3月,在CAB直接,科学网和PubMed数据库中搜索了同行评审的文章.
- 排除标准包括非英语文章,非同行评审的研究,无关的PICO或专注于现有瘤或预后而不是发展的研究.
主要成果:
- 在最初的232篇文章中,有13篇符合纳入标准.
- 一个重要的发现是,在13项选定的研究中,有6项没有发现任何证据支持早期消毒对乳腺瘤发展的保护作用.
结论:
- 目前的文献表明,早期消毒对乳腺瘤的保护作用并没有得到一致的支持.
- 建议进一步进行与匹配的对照进行特定品种的研究,以解决偏见和混因素.
- 在确定化狗的最佳年龄时,应仔细权衡早期化的好处与其他因素.
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