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Updated: May 28, 2025

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与心血管疾病相关的非编码变体破坏了GATA4-DNA结合和调节功能

Edwin G Peña-Martínez1, Jean L Messon-Bird1, Jessica M Rodríguez-Ríos1

  • 1Department of Biology, University of Puerto Rico-Río Piedras, San Juan, PR 00931, USA.

HGG advances
|February 13, 2025
PubMed
概括

研究人员确定了与心血管疾病 (CVD) 相关的遗传变异,这些变异破坏了心脏转录因子GATA4.4的结合. 这些变异改变了基因调节,为心血管疾病发展提供了洞察力.

关键词:
结合 DNA 的结合.心血管疾病心血管疾病基因调节 基因调节 基因调节没有编码的变体.转录因子是一种转录因子.

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