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在喀麦隆,将型肝炎的检测和治疗纳入常规艾滋病毒护理是可行的

Mathurin Pierre Kowo¹, Liza Coyer^2,3, Victor Sini^4,5

¹Research Laboratory on Viral Hepatitis and Health Communication, University of Yaoundé I, Yaoundé, Cameroon.

Journal of the International AIDS Society

|February 13, 2025

概括

在喀麦隆,将型肝炎病毒 (HCV) 检测和治疗整合到艾滋病毒治疗中,诊断出了新病例,并实现了高治愈率. 这一战略对消除HCV有希望,但需要改进获得和能力.

科学领域:

传染性疾病传染性疾病
肝病学肝病学是一种肝病学.
公共卫生公共卫生

背景情况:

肝炎C病毒 (HCV) 感染对患有人类免疫缺陷病毒 (HIV) 的人来说构成更大的风险.
对于喀麦隆的艾滋病毒感染者来说,人们对HCV的患病率和诊断/治疗的准入程度知之甚少,而且有限.
将HCV服务整合到常规HIV护理中可以提高诊断和治疗覆盖率.

研究的目的:

确定喀麦隆艾滋病毒感染者中HCV的流行率.
为了评估这一群体中HCV治疗治愈率.
评估将HCV服务整合到现有艾滋病毒诊所的可行性.

主要方法:

提供HCV抗体和RNA测试给8266名21岁以上的接受艾滋病毒抗逆转录病毒治疗 (ART) 且病毒载量受抑制的个人.
阳性HCVRNA病例接受了12周的索福斯布维尔/韦尔帕塔斯维尔治疗.
治疗后12周的持续病毒学反应 (SVR12) 定义的治愈率.

主要成果:

感染HCV抗体的流行率为3.8% (316/8266),其中87.8% (251/286) 具有可检测的HCVRNA.
在173名注册者中,165人完成了治疗,SVR12率达到93.6%.
完成治疗的人显示SVR12率为98.2%;所有参与者最终都被治愈了.

结论:

在喀麦隆,将HCV检测和治疗纳入常规HIV护理是可行的.
该研究实现了高的HCV治愈率,支持其消除HCV的潜力.
为了更广泛的实施,需要提高测试普及率,获得诊断/治疗和实验室能力.

关键词:

喀麦隆 - 喀麦隆 - 喀麦隆艾滋病病毒艾滋病病毒艾滋病病毒诊断诊断诊断诊断诊断诊断直接作用的抗病毒药物.在C型肝炎病毒的感染中,实施科学实施科学

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