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转化生长因子-β调节肝细胞癌的CD44亚种群上的癌症干细胞特征

Mario Alejandro Aguilar-Chaparro1, Sonia Andrea Rivera-Pineda1, Hury Viridiana Hernández-Galdámez1

  • 1Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV), México City, México.

Journal of cellular biochemistry
|February 13, 2025
PubMed
概括

转化生长因子-β (TGF-β) 通过调节CD44标准 (CD44std) 和CD44变异9 (CD44v9) 亚群,改变肝细胞癌 (HCC) 中的癌症干细胞 (CSC) 特性,影响MAPK信号传递和细胞行为.

关键词:
CD44 的同位体形式.癌症干细胞是癌症干细胞.表皮细胞-介质细胞过渡.肝细胞癌是肝细胞癌.转变的增长因子-beta.

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