与衰老相关的肠道失调症恶化了小鼠的认知能力
Huihui Ju1, Yile Zhou1, Wanting Wei2
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Acta biochimica et biophysica Sinica
|February 13, 2025
概括
老化会影响认知,但将年轻的肠道微生物移植到老老鼠身上可以恢复认知功能. 这涉及增加有益细菌和酸水平,为与年龄相关的认知衰退提供了潜在的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 老年学是一门学科.
背景情况:
- 老龄化是认知功能障碍的主要危险因素.
- 肠道微生物群组成的变化与衰老中的认知能力下降有关.
- 了解衰老中的肠-大脑轴对于开发干预措施至关重要.
研究的目的:
- 调查肠道微生物群变化在与年龄相关的认知障碍中的作用.
- 探索肠道微生物群移植用于老年小鼠认知增强的治疗潜力.
主要方法:
- 使用新型物体识别和T迷宫测试对年轻和老年小鼠进行认知功能评估.
- 从年轻小鼠移植到老鼠的便微生物群移植.
- 对肠道微生物群组成,肠道蛋白质表达 (mucin-2,E-cadherin) 和海马区蛋白质表达 (synaptophysin) 的分析.
- 在体外诱导神经元衰老,评估蛋白质表达和ATP水平.
主要成果:
- 与年轻小鼠相比,老年小鼠表现出显著的认知功能障碍.
- 便微生物种移植在老年小鼠中部分恢复了认知能力,并改善了海马突触素水平.
- 移植使肠道粘素-2和E-cadherin的表达正常化,并增加了特定Lactobacillus物种的丰富性.
- 通过移植增加的酸被证明可以改善神经元衰老标志物和ATP生产.
结论:
- 肠道微生物移植可以改善老年相关的小鼠认知衰退.
- 恢复特定的肠道细菌 (乳酸菌) 和增加酸水平是关键机制.
- 便微生物群移植对抗衰老中的认知障碍具有治疗性前景.
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