在COVID-19患者中不成熟的血小板和血小板活性
Yulia Balmakov1, Tomer Mark2,3, Itzik Barnett2,3
1Department of Military Medicine and "Tzameret", Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel, and Medical Corps, Israel Defense Forces, Jerusalem, Israel.
概括
与败血症患者相比,严重的COVID-19患者的不成熟血小板计数 (IPC) 较高. 这表明不成熟的血小板可能表明COVID-19的严重程度,与CRP水平不同.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 存在高血栓栓塞事件的高风险.
- 目前缺乏指导COVID-19抗血栓治疗的标志物.
- 不成熟的血小板具有过度反应性,并与动脉血栓形成有关.
研究的目的:
- 为了比较严重的COVID-19患者和败血症患者的不成熟血小板指数.
- 调查未成熟血小板计数 (IPC) 作为COVID-19严重程度的生物标志物的潜力.
主要方法:
- 一项前性研究,将53名严重的COVID-19患者与41名败血症患者进行比较.
- 使用Sysmex XN-3000测量了血小板计数,不成熟血小板分数 (IPF) 和IPC.
- 在入院和随后的时间点进行测量.
主要成果:
- 与败血症患者 (9 × 10 ^ 9 / L) 相比,COVID-19患者入院后三天 (13.4 × 10 ^ 9 / L) 的IPC水平显著更高.
- COVID-19 患者表现出血小板周转率和反应性增加,由较高的不成熟血小板指数表明.
- 一些接受托西利祖马布治疗的COVID-19患者的C-反应蛋白 (CRP) 水平下降,但没有明显的临床改善.
结论:
- 在严重的COVID-19患者中,不成熟的血小板指数,特别是IPC,升高,这表明血小板周转率增加.
- 不成熟的血小板可以作为评估COVID-19疾病严重程度的宝贵生物标志物.
- 在COVID-19患者中,CRP可能不是疾病严重程度的可靠指标.
相关概念视频
01:18Structure and Function of Platelets
959
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
959
01:22Formation of the Platelet Plug
3.9K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
3.9K
01:24Disorders of Hemostasis
686
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
686
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
461
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
461