血统特定的A类GPCR动态反映了Lophotrochozoa中的多种化学感官适应
Rohan Nath1, Biswajit Panda1, Siuli Rakesh1
1Department of Biological Sciences, Indian Institute of Science Education and Research Berhampur (IISER Berhampur), Berhampur 760010, India.
Molecular biology and evolution
|February 13, 2025
概括
在Lophotrochozoa中的A类G蛋白结合受体 (GPCR) 显示与不同的环境适应和化学传感作用相关的谱系特异性扩张. 这些发现平行于deuterostomes的趋势,突出了化学接收中保存的进化模式.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 类A G蛋白结合受体 (GPCRs) 对化学感知至关重要,影响动物的行为和进化.
- 通过GPCRs的化学接收在脊椎动物中得到了很好的研究,但在Lophotrochozoa,一个多样化的原始体群中了解得很少.
研究的目的:
- 在Lophotrochozoa中研究A类GPCRs的进化动态.
- 识别与各种息地和生活方式中化学感应适应相关的谱系特定GPCR扩张.
主要方法:
- 对238个lophotrochozoan基因组进行比较基因组学分析.
- 基于基因组学和正义学推断的聚类来识别GPCR子集.
- 对序列异质性,阳性选择和带结合口袋的分析.
主要成果:
- 在Lophotrochozoa中识别了A类GPCRs的显著谱系特异性扩张,与息地和生活方式适应相关.
- 在适应极端环境或寄生虫生活方式的物种中发现了GPCR扩张的减少.
- 从保存的GPCR中分辨出适应性扩张,并注意到全基因组重复的有限影响.
结论:
- 在Lophotrochozoa中A类GPCR演变的特点是广泛的,由化学传感适应驱动的谱系特异性扩张.
- 这些发现揭示了与deuterostome血统的进化平行.
- 这项研究为未来关于lophotrochozoan化学接收的研究提供了基因组基础.
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