在北京的一些地区对维生素K的参考间隔进行初步研究,对人口进行正常体检
Lin Chen1, Meiqi Chen1, Shi Cheng1
1Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Journal of nutritional science
|February 13, 2025
概括
这项研究确定了在健康的北京人群中血清维生素K1 (VK1),menaquinone-4 (MK4) 和menaquinone-7 (MK7) 的参考间隔. 这些发现为临床应用和对维生素K水平的进一步研究提供了关键数据.
科学领域:
- 生物化学 生物化学
- 临床化学 临床化学
- 营养科学 营养科学
背景情况:
- 维生素K (VK) 含量在地域和人口之间存在显著差异.
- 在健康人群中缺乏确定的VK参考间隔,这阻碍了准确的临床评估.
- 了解VK状态对于各种生理过程至关重要,包括骨健康和血液凝固.
研究的目的:
- 在北京的健康个体中建立和验证血清维生素K1 (VK1),menaquinone-4 (MK4) 和menaquinone-7 (MK7) 的参考间隔.
- 为这些关键的维生素K形式提供特定年龄的参考范围.
- 评估推导的参考间隔的临床适用性.
主要方法:
- 来自434名健康个体的血清样本使用高性能液态染色学和质谱学分析了VK1,MK4和MK7.
- 使用测量数据的2.5和97.5百分位数来确定参考间隔.
- 进行了初步验证,对60名看似健康的个人进行了例行体检.
主要成果:
- 在被研究的人群中为VK1,MK4和MK7建立了特定年龄的参考间隔.
- 例如,VK1参考间隔因年龄组而异,在年轻人群中从0.180 ng/mL到1.494 ng/mL不等.
- 此外,MK4和MK7在不同年龄层中也显示出不同的参考间隔,MK7的间隔通常高于MK4.
结论:
- 不同年龄组的VK1,MK4和MK7所确定的参考间隔证明了其临床适用性.
- 这些发现为未来的多中心研究和与维生素K状况相关的临床诊断提供了重要的数据支持.
- 该研究强调了为准确解释维生素K水平而建立特定人群参考范围的重要性.
关键词:
ALT,氨酸氨基转移酶,氨酸氨基转移酶.AST,阿斯巴酸氨基转移酶,阿斯巴酸氨基转移酶显然正常的人口.体重指数 (BMI),身体质量指数.Cr,肌氨酸,肌氨酸是什么意思FG, 禁食葡萄糖 禁食葡萄糖高密度脂蛋白胆固醇 (HDL-C) 是一种高密度脂蛋白胆固醇.Hb, 血球蛋白 血球蛋白低密度脂蛋白胆固醇 (LDL-C) 是一种低密度脂蛋白胆固醇.在MK4,Menaquinone-4中使用.在MK7中,Menaquinone-7为MK7,Menaquinone-7为MK7,Menaquinone-7为MK7,Menaquinone-7为MK7,Menaquinone-7为MK7,Menaquinone-7为MK7,Menaquinone-7为MK7营养状态 营养状况参考时间间隔是指参考时间间隔.血清中的血清水平.血压,胆固醇,胆固醇的使用.TG,甘油三,甘油三.UA,尿酸,尿酸的使用情况.维基K1,维生素K1,维生素K1维生素K 维生素K是一种维生素.ng/ml,每毫升纳米克.更多相关视频
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