预设的饮食质量和修改的自然循环体外受精结果
Janine P M Faessen1, Irene Homminga2, Marion E C Buso1
1Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Journal of nutritional science
|February 13, 2025
概括
对2015年荷兰健康饮食的更高坚持意外地与在体外受精 (MNC-IVF) 经过修改自然周期的妇女中持续怀孕和活产的可能性较低有关. 需要进一步的研究,以在更大的群体中探索这些发现.
科学领域:
- 生殖医学 生殖医学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 饮食模式影响体外受精 (IVF) 的成功,但证据仍然不确.
- 荷兰健康饮食2015 (DHD2015) 准则为健康饮食提供了一个框架.
- 坚持DHD2015和IVF结果之间的关联需要进一步调查.
研究的目的:
- 调查遵守DHD2015指南与经过修改自然周期体外受精 (MNC-IVF) 的妇女怀孕结果之间的关系.
主要方法:
- 一项针对109名接受MNC-IVF的妇女进行的前性队列研究.
- 饮食摄入量通过每日食物记录进行评估,并通过DHD2015指数量化.
- 试管婴儿结果 (怀孕测试,正在进行的怀孕,活产) 分析使用Cox比例危险回归,以年龄,BMI和吸烟等共变量进行调整.
主要成果:
- 对DHD2015的更高遵守与持续怀孕 (HR=0.77) 和活产 (HR=0.78) 的可能性降低有关.
- 对较低的阳性妊娠测试率的非显著趋势被观察到与更高的DHD2015坚持 (HR=0.85).
- 这些反向关联在特定子组中更为明显,包括那些接受多国细胞内注射 (ICSI) 和超重的女性.
结论:
- 这项探索性研究表明,遵守DHD2015指南与MNC-IVF成功率之间存在意想不到的反向关联.
- 需要进一步的大规模分层研究来验证和理解这些发现.
- 结果强调了在生育治疗中需要细微的饮食建议.
关键词:
辅助生殖技术 (ART) 是一种辅助生殖技术.体重指数 (BMI),人体质量指数.DHD2015,荷兰健康饮食2015年饮食质量 饮食质量ICSI,细胞体内精子注射,细胞体内精子注射.试管婴儿,体外受精,体外受精.不孕不育 不孕不育 不孕不育跨国IVF,修改后的自然循环体外受精.在体外受精中修改自然循环.预先设想的概念怀孕 怀孕 怀孕 怀孕UMCG,格罗宁根大学医学中心更多相关视频
12:32Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
Published on: September 7, 2021
2.1K
06:11Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
Published on: May 17, 2024
491
相关概念视频
In Vitro Fertilization
203
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
203
Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Ovarian Cycle
940
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
940
Infertility in Females
264
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
264
Fertilization
70.7K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
70.7K
Infertility in Males
235
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
235
