GutBugDB:一个网页资源,预测人类肠道微生物组介导生物转化生物和异生物分子的肠道微生物
Usha Longwani1, Ashok K Sharma1, Aditya S Malwe1
1MetaBioSys Lab, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh, India.
Gut microbiome (Cambridge, England)
|February 13, 2025
概括
人的肠道微生物群显著影响药物代谢. GutBugDB是一个新的数据库,预测肠道微生物如何转化药物和营养保健品,有助于开发新疗法.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 生物信息学是一种生物信息学.
背景情况:
- 人体肠道微生物群在口服化合物的代谢中起着至关重要的作用.
- 了解微生物对异生菌和生物分子转化的贡献,是药物和营养药物开发的关键.
研究的目的:
- 介绍GutBugDB,这是一个开放式数字存储库,用于预测肠道微生物组介导的生物转化.
- 提供对药物和营养食品的特定物种微生物代谢的见解.
主要方法:
- 使用690个肠道细菌基因组的代谢蛋白构建数据库.
- 包括363,872种具有EC号码,Expasy ID和域信息的蛋白酶.
- 使用GutBug工具来预测生物转化.
主要成果:
- GutBugDB包含有关1439种FDA批准的药物和营养食品的肠道微生物群酶介导的代谢生物转化信息.
- 该数据库利用来自GutBug工具的预测.
结论:
- GutBugDB促进了对肠道微生物组与药物相互作用的研究.
- 这种资源可以通过调节肠道微生物群来帮助开发新的治疗和营养分子.
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