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在单个欧卵性母细胞囊移植后,与流产相关的危险因素
Xiaohui Dong1, Juanzi Shi1, Xiaohua Liu1
1Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.
Frontiers in endocrinology
|February 13, 2025
概括
胚胎移植后的妊娠损失与母亲吸烟,第6天胚胎细胞移植以及触发日的激素水平有关. 这些因素增加了妊娠损失的风险后euploid胚胎转移.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 遗传学 是一个遗传学.
背景情况:
- 重复流产 (RPL) 和植入失败是辅助生殖技术 (ART) 的重大挑战.
- 欧卵母细胞移植旨在提高植入率,但仍然发生妊娠损失 (PL).
- 在euploid转移后确定影响PL的因素对于优化ART结果至关重要.
研究的目的:
- 为了确定影响妊娠流产 (PL) 的主要因素,经过euploid胚胎囊的转移.
- 为了分析与PL相关的变量,在经历euploid胚胎细胞移植的队列中.
主要方法:
- 追溯队列研究分析了来自270个单个欧卵母细胞移植的数据.
- 用二进制物流回归分析来确定影响PL的重要因素.
- 检查的变量包括触发日的激素水平 (雌激素[E2],黄蛋白化激素[LH]),卵细胞产量,女性BMI,母亲吸烟状况和胚胎细胞移植日.
主要成果:
- 该PL率为13.3% (36/270个案例).
- 与PL风险增加相关的因素包括较高的LH水平,触发日较低的E2水平,母亲吸烟以及第6天的胚胎细胞转移.
- 与活产子组相比,PL组的E2较低,LH较高,取回卵细胞较少,女性BMI较高,吸烟者的比例较高.
结论:
- 孕妇吸烟,胚胎移植日 (6日),雌激素 (E2) 水平,以及触发日的黄激素 (LH) 水平与欧胚胎移植后的妊娠损失有显著的相关性.
- 这些发现突出了可修改和不可修改的因素,这些因素可能会影响欧胚胎移植的成功.
- 进一步的研究可以探索干预措施,以减轻与这些已确定因素相关的风险.
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