与代谢功能障碍相关的脂肪肝疾病增加了慢性病的风险:系统性审查和元分析
Jianghua Zhou1, Dan-Qin Sun2, Giovanni Targher3
1Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
eGastroenterology
|February 13, 2025
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显著增加患慢性病 (CKD) 的风险. 这一元分析证实MAFLD与流行和发病的CKD有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是非酒精性脂肪肝疾病 (NAFLD) 的拟议重新分类.
- 与NAFLD分类相比,MAFLD可能具有更好的临床实用性.
- MAFLD与慢性病 (CKD) 之间的关联需要进一步调查.
研究的目的:
- 量化MAFLD与流行和发病的CKD风险之间的关联.
- 综合MAFLD和CKD风险观察性研究的证据.
主要方法:
- 在多个数据库 (PubMed,Medline,Embase,Web of Science,Cochrane Library) 进行系统的文献搜索,直到2022年5月.
- 包括评估MAFLD和CKD的观察性研究 (定义为eGFR ≤60mL/min/1.73m2或白色素尿).
- 使用随机效应模型进行元分析,以计算 95% 置信区间 (CI) 的聚合危险比率 (HR) 和赔率比率 (OR).
主要成果:
- 包括17项观察性研究,共845753名参与者.
- 在队列研究中,MAFLD与29%的发生性CKD风险增加有关 (HR 1.29,95%CI 1.17-1.41).
- 在横截面研究中,MAFLD与患有常见CKD的风险增加35% (OR1.35,95%CI1.11-1.64).
结论:
- MAFLD与慢性脏病的患病率增加有显著的关联.
- MAFLD也与较高的CKD发病率有显著的联系.
- 这些发现支持MAFLD作为CKD发展的重要因素.
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