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具有多种药物耐药性的ESBLE. 城市地表水中的大肠杆菌和公共卫生影响:达卡戈兰查特巴里的一个案例研究

Md Sakib Hossain¹, Ahmed Ishtiaque Amin Chowdhury², Mohammad Rafiqul Islam¹

¹Laboratory of Environmental Health, Health Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, 1212, Bangladesh.

|February 13, 2025

概括

孟加拉国的城市地表水被产生大肠杆菌的多抗药性 (MDR) 扩展光谱β-乳糖酶 (ESBL) 污染. 这些病原体对公共健康构成重大风险,增加了水源性疾病和抗生素耐药性.

科学领域:

环境科学环境科学
微生物学微生物学
公共卫生公共卫生

背景情况:

表面水污染是一个全球危机,城市化和卫生设施不足加剧了这种危机,特别是在发展中国家.
在地表水中产生*大肠杆菌*的致病性扩展谱β-乳糖酶 (ESBL) 的存在是一个关键的公共卫生问题,与水传播疾病和多药性耐药性 (MDR) 感染的传播有关.

研究的目的:

调查孟加拉国城市地表水中的ESBL产生大肠杆菌的流行率和特征.
分析ESBL生产的分子基础,病原性,抗生素耐药性,生物膜形成和这些隔离物的遗传多样性.

主要方法:

从地表水样本中隔离和识别大肠杆菌.
对ESBL生产的表型和基因型分析 (CTX-M,TEM,SHV,OXA基因).
检测致病基因 (ETEC,EIEC,ExPEC),抗生素敏感性测试,生物膜测定和ERIC-PCR用于遗传多样性.

主要成果:

在所有样本中检测到大肠杆菌,其中23.31%的分离物是表型ESBL阳性.
CTX-M是最常见的ESBL基因 (88.71%). 病原体分离物包括ETEC (40.32%) 和ExPEC.
所有ESBL分离物都是MDR,对β-乳酸盐具有很高的耐药性,并且能够形成生物膜. 埃里克PCR发现了14个不同的遗传集群.

结论:

达卡的城市地表水受到致病性,MDRESBL产生*大肠杆菌*的严重污染,对公众健康构成严重威胁.
这些发现凸显了改善水处理,卫生和环境管理的迫切需要,以减轻水传播疾病和抗菌素耐药性的风险.

关键词:

孟加拉国孟加拉国孟加拉国在ESBL中,大肠杆菌.它具有多种药物耐药性.致病性致病性致病性公共卫生公共卫生表面的水是表面的水.水传染性疾病是通过水传播的.

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