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未来的效应器:通用化学抗原受体

Lara Sophie Schlegel1, Patrick Schlegel1,2

  • 1School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
|February 13, 2025
PubMed
概括

使用工程免疫细胞的下一代细胞疗法在耐火性B系恶性瘤中显示出高缓解率. 万能适配器仿真抗原受体 (CAR) 技术为多目标免疫疗法提供了一个多功能平台.

关键词:
适配器仿真抗原受体技术的技术.抗体依赖的细胞细胞毒性癌症免疫疗法癌症免疫疗法化学抗原受体工程 化学抗原受体工程多目标定位 多目标定位

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Diversity of Antigen Receptors01:28

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...