对肝移植潜在活体供体进行分阶段的手术前评估
Camila Sotomayor1, Daniel García1, Patricia Rebolledo1
1Department of Digestive Surgery, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Translational gastroenterology and hepatology
|February 13, 2025
概括
只有三分之一的潜在活着的肝脏捐赠者适合捐献. 早期的计算机断层扫描 (CT) 扫描有助于降低成本,在广泛的检查之前识别不合适的候选人.
科学领域:
- 移植手术 移植手术
- 肝病学 肝病学是一种肝病学.
- 手术瘤学手术瘤学
背景情况:
- 活体供体肝移植 (LDLT) 对于改善接受者结果和最大限度地降低供体风险至关重要.
- 严格的供体选择对于成功的LDLT计划至关重要.
- 本研究分析了在特定的LDLT计划中供体选择流程和供体排除的原因.
研究的目的:
- 描述活体供体肝移植计划中供体选择过程.
- 评估排除潜在活体肝脏捐献者的原因.
- 确定影响捐赠者适合性和接受率的因素.
主要方法:
- 在2018年4月至2021年7月期间评估的潜在活体肝脏捐赠者的回顾性分析.
- 纳入标准:年龄在18-60岁之间,没有明显的医疗/精神相关疾病,ABO和解剖适应性.
- 数据收集包括评估不完整和解剖不合适的原因.
主要成果:
- 评估了231名潜在捐赠者;75名 (32.5%) 被接受,36名 (15.6%) 接受了捐赠.
- 43.7%的人没有完成评估,原因是已故的捐赠者可用性,ABO不兼容性或接受者进展/死亡.
- 在完成放射性评估的人中,42.3%的人在解剖学上不适合,主要是由于肝脏残留物大小小小或脂肪瘤.
结论:
- 只有不到三分之一的潜在活着的肝脏捐赠者最终适合捐献.
- 大约一半的合适捐赠者会进行肝脏捐赠手术.
- 在评估过程的早期利用计算机断层扫描 (CT) 可以通过有效地排除解剖学上不合适的捐赠者来降低成本.
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