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果实:植物学,应用,加工,植物化学,质量控制,药理学和毒理学的综述

Yule Hao¹, Jiawen Qi¹, Xinggui Huang¹

¹School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in pharmacology

|February 13, 2025

概括

传统中医药中的一种Euodiae Fructus (EF) 具有多种药理作用,但也具有轻微的毒性. 需要进一步的研究来了解其机制,并减轻安全发展的风险.

科学领域:

药理学和毒理学药理学和毒理学
传统中国医学 (TCM) 是一种
植物化学植物化学

背景情况:

Euodiae Fructus (EF),源自*Euodia rutaecarpa*,是一种TCM,历史上用于各种疾病.
EF被认为具有缓解疼痛,抗,抗腹等作用,但具有轻微的毒性.
目前的TCM应用包括腹部疼痛,胃炎,刺激性肠综合征和经期障碍.

研究的目的:

综合审查 EF 的植物特性,传统用途,加工,植物化学,质量控制,药理学和毒理学.
确定知识缺口,特别是EF的心脏毒性和毒性以及其代谢物机制.
为EF的高价值发展提供基础.

主要方法:

关于2024年9月之前的出版物的文献综述.
从经典的TCM文本和科学数据库 (Web of Science,PubMed,Elsevier,ACS,ResearchGate,Google Scholar,CNKI) 的数据进行分析.
专注于已识别的代谢物,药理作用和毒理特征.

主要成果:

在EF中发现的300多种代谢物表现出不同的药理作用,包括心血管,胃肠道和神经保护,抗炎症,止痛,抗瘤和代谢调节.
EF显示有毒性,影响肝脏,心脏和脏;对心脏毒性和毒性的研究是有限的.
关键的活性化合物包括埃沃胺,鲁他卡和利蒙因,这也会导致毒性; 利蒙因和其他代谢物被研究不足.

结论:

EF是一种有价值的TCM,具有显著的治疗潜力,但由于其毒性,需要谨慎管理.
质量控制的标准化和对毒性减轻的加工方法的进一步调查至关重要.
对EF及其代谢物的药理和毒理机制进行深入的研究是必要的,以确保安全有效的利用.

关键词:

这就是 Euodiae Fructus.药理学药理学药理学药理学药理学植物化学植物化学处理处理处理处理质量控制质量控制质量控制毒理学毒理学毒理学传统的使用传统的使用.

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