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动物菌 (Bifidobacterium animalis) 的亚种. 乳糖TG11通过调节肠道微生物群来改善小鼠的洛佩拉胺诱导的便秘

Weiwei Ma¹, Yiyang Zhao¹, Yuyang Liu¹

¹College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China.

Frontiers in microbiology

|February 13, 2025

概括

生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖TG11通过改善肠道运动性和正常化肠道微生物群,有效地预防小鼠的便秘. 这种益生菌在治疗胃肠道疾病方面表现有前途.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

便秘是一种普遍的胃肠道疾病,影响生活质量.
益生菌越来越多地被认为是它们在治疗便秘方面的潜在治疗益处.

研究的目的:

为了研究Bifidobacterium animalis亚种的预防作用. 在小鼠模型中,乳糖TG11对洛佩拉胺诱导的便秘.
阐明TG11在缓解便秘方面的有效性背后的机制.

主要方法:

给小鼠服用不同剂量的TG11或盐水,然后用洛佩拉胺诱导便秘.
评估的参数包括肠道移动性,便含水量,肠道水平和结肠基因表达 (SCF,c-kit).
通过元基因组测序分析了便短链脂肪酸和肠道微生物群组成.

主要成果:

在患有便秘的小鼠中,TG11显著改善了肠道运动性,并维持了便中的水含量.
肠道水平正常化和结肠SCF和c-kit mRNA表达的上调.
TG11调节了肠道微生物群,增加了像Muribaculum_sp.这样的有益细菌. 和未经培养的Duncaniella.

结论:

生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖TG11在改善便秘方面表现出显著的疗效.
TG11的治疗作用可能通过调节肠道微生物群的组成和功能来调节.

关键词:

在SCF/c-kit中使用.便秘便秘便秘便秘我们的肠道微生物群.肠道酸是一种肠道酸.益生菌是一种益生菌.

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