用单粒子ICP-QMS和ICP-TOFMS测量纳米粒子和微粒子的挑战:尺寸依赖的运输效率和有限的线性动态范围
Madeleine Lomax-Vogt1,2, Lucas M Carter1, Jonas Wielinski3
1Trace Element Research Laboratory, School of Earth Sciences, The Ohio State University Columbus OH 43210 USA olesik.2@osu.edu.
Journal of analytical atomic spectrometry
|February 13, 2025
概括
单粒子感应合等离子体质谱法 (spICP-MS) 可以通过扩大其线性动态范围来测量微粒. 降低仪器灵敏度可以准确测量最大的粒子,直至5000nm.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 单粒子感应合等离子体质谱法 (spICP-MS) 主要用于纳米粒子量化.
- 使用spICP-MS测量微粒带来了挑战,因为粒子大小依赖于运输效率和需要广泛的线性动态范围.
研究的目的:
- 调查spICP-MS对纳米粒子和微粒子的线性和动态范围限制.
- 对于较大的颗粒来说,描述spICP-MS信号中非线性原因.
- 确定用于微粒子分析的spICP-MS线性动态范围扩展的方法.
主要方法:
- 使用spICP-MS.分析了工程SiO2颗粒 (500-5000nm) 和Au颗粒 (60-1500nm).
- 仪器灵敏度被系统地降低,以评估其对线性动态范围的影响.
- 粒子信号强度与粒子质量相关,以评估线性.
主要成果:
- 降低spICP-MS灵敏度显著扩大了粒子大小的线性动态范围的上限.
- 降低灵敏度允许测量高达5000nm的SiO2颗粒,与ICP中完全蒸发相一致.
- 增加的降低灵敏度扩大了粒子质量的线性动态范围,但也增加了可检测的最小粒子大小.
结论:
- 通过优化仪器灵敏度,spICP-MS能够测量微粒.
- 灵敏度调整对于扩大线性动态范围和准确量化较大的粒子至关重要.
- 这些发现支持ICP中SiO2微粒的完全蒸发,使其能够通过spICP-MS进行分析.
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