尿液估计盐摄入量与高血压之间的关联:基于人口的研究结果
Zahra Bahadoran1, Parvin Mirmiran2, Asghar Ghasemi3
1Micronutrient Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
高盐摄入量与高血压风险增加有关,特别是在早期阶段和腹压. 减少盐的摄入量可能有助于预防高血压的发展.
科学领域:
- 心血管健康 心血管健康
- 脏生理学 脏生理学
- 营养流行病学 营养流行病学
背景情况:
- 高血压 (HTN) 是一个重要的公共卫生问题.
- 饮食盐摄入量是HTN的可修改风险因素.
- 了解盐摄入量与HTN阶段/表型之间的特定关联对于有针对性的干预至关重要.
研究的目的:
- 调查尿液估计盐摄入量与多阶段高血压之间的关联.
- 为了检查盐摄入量和不同类型的高血压之间的表型特异性联系.
- 探索盐摄入量在高血压前期和已确定的高血压发展中的作用.
主要方法:
- 横截面研究设计. 截面研究设计.
- 包括1782名来自德黑兰脂质和葡萄糖研究 (2015-2017年) 的成年参与者.
- 使用24小时尿液 (24hU) 来估计盐摄入量和测量血压 (BP);采用多变量调整的多项逻辑回归.
主要成果:
- 前HTN,第一阶段HTN和第二阶段HTN的患病率分别为5.7%,29.3%和9.1%.
- 较高的盐摄入量 (>10.9克/天) 与前HTN,第一阶段HTN,隔离的透气性HTN (IDH) 和静脉-透气性HTN (SDH) 的几率增加有关.
- 每增加1g/天超过5g/天与HTN前,第一阶段HTN和IDH的更高几率相关.
结论:
- 高盐摄入量有助于高血压的发展,特别是在早期的血压升高阶段.
- 高盐摄入量的影响可能比静缩血压对透静血压的影响更大.
- 研究结果表明,减少盐的摄入量可能是管理和预防高血压的关键策略.
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