维生素水平与老年关节骨折之间的关联:一个横截面研究
Qifei He1, Chun Zhang1, Wei Xie1
1Department of Orthopedics, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Frontiers in nutrition
|February 13, 2025
概括
与健康人相比,老年关节骨折患者的维生素A,B9和K1水平较低. 维生素A可能是预防老年人骨折的关键因素.
科学领域:
- 老年医学 老年医学
- 营养科学 营养科学
- 整形外科 整形外科 整形外科
背景情况:
- 老年人骨折与营养缺乏有关,特别是维生素D.
- 其他维生素在老年人骨折的发展中的作用尚不清楚.
研究的目的:
- 为了确定患有骨骨折的老年患者的维生素水平和缺乏症.
- 为了比较部骨折患者和健康的老年人之间的维生素水平.
主要方法:
- 在210名骨折患者和402名健康对照者 (≥65岁) 中测量了各种维生素 (A,B1,B2,B3,B5,B6,B9,E,K1和25-氧维生素D) 的血清水平.
- 评估了营养标志物,包括预后营养指数 (PNI).
- 进行了相关性和多重线性回归分析,以确定维生素水平与部骨折风险之间的关联.
主要成果:
- 与对照组相比,部骨折患者的维生素A,B1,B3,B5,B9,25-氧维生素D,E和K1水平显著降低 (p <0.05).
- 两组超过80%的参与者表现出维生素D缺乏.
- 回归分析发现维生素B9 (β = -0.94),维生素A (β = -0.83) 和维生素K1 (β = -0.80) 与部骨折风险显著相关.
结论:
- 维生素D缺乏症在老年人中很普遍,无论骨折状况如何.
- 与健康对照人群相比,关节骨折患者的维生素A,B9和K1水平显著降低,独立于年龄和性别.
- 维生素A成为预防老年人骨折的潜在治疗标.
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