代谢类固醇使用者的心血管疾病
Josefine Windfeld-Mathiasen1,2, Ida M Heerfordt1, Kim Peder Dalhoff1,2
1Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark (J.W.-M., I.M.H., K.P.D., J.T.A., M.A.A., K.S.J., H.H.).
Circulation
|February 13, 2025
概括
类固醇类固醇 (AAS) 使用显著增加心血管事件的风险,包括心脏病发作和心力衰竭. 这项大规模的研究证实,与普通人群相比,阿片类药物使用者的风险大大增加.
科学领域:
- 心脏病学
- 内分泌学
- 公共卫生
背景情况:
- 类固醇类固醇 (AAS) 的使用与死亡率的增加有关,心血管疾病与一些死亡有关.
- 对AAS使用者的心血管健康影响仍未得到充分研究.
- 这项研究研究了男性使用阿斯的心血管疾病发病率与一般人群的情况.
研究的目的:
- 量化男性使用AAS的心血管疾病发病率.
- 为了比较AAS使用者的心血管疾病率与相匹配的一般人口队列.
- 为了确定与AAS使用相关的特定心血管风险.
主要方法:
- 在丹麦 (2006年至2018年) 实施制裁的男性使用者队列建立.
- 从丹麦普通人口中选择了一个年龄和性别匹配的50:1对照组.
- 全国范围的登记处追踪了心血管事件 (例如心肌梗塞,心肌病) 和其他健康数据,直到2023年6月.
主要成果:
- 在11年的随访期间,AAS使用者 (n=1189) 的心血管事件发生率明显高于对照者 (n=59,450).
- 使用AAS与急性心肌梗塞 (aHR 3. 00),复血管化手术 (aHR 2. 95),静脉血栓塞 (aHR 2. 42),心律失常 (aHR 2. 26),心肌病 (aHR 8. 90) 和心力衰竭 (aHR 3. 63) 的风险增加有关.
- 在AAS使用者中,缺乏关于缺血性中风和心脏骤停发病率的数据.
结论:
- 类固醇使用与心血管疾病的风险大大增加有关.
- 这些发现突出了与AAS消费相关的显著心血管危险.
- 这项研究强调了对AAS相关心血管风险的认识和预防策略的需要.
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