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体重过重和肥胖儿童的身体组成和MASLD的性别差异
Adi Uretzky1,2, Eyal Cohen-Sela1,2, Michal Yackobovitch-Gavan3
1The Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Acta paediatrica (Oslo, Norway : 1992)
|February 13, 2025
概括
身体成分会影响超重儿童的肝脏健康. 较低的肌肉与脂肪比率 (MFR) 与肝脏肥胖症的几率增加有关,这凸显了对有风险的年轻人进行评估的需要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肝病学 肝病学是一种肝病学.
- 身体组成分析 身体成分分析
背景情况:
- 儿童超重和肥胖与非酒精性脂肪性肝病 (NAFLD) 有关.
- 了解身体组成和肝脏健康之间的相互作用对于早期干预至关重要.
研究的目的:
- 为了研究体质成分指标,肝纤维化指标和超重/肥胖儿童的超声波肝硬化症之间的关联.
- 为了确定这些关系中的潜在的性别特异性差异.
主要方法:
- 170名超重/肥胖儿童接受了生物电阻分析,以测量身体成分 (脂肪百分比,骨干与总脂肪比,肌肉与脂肪比 (MFR)).
- 肝脏评估包括肝脏肥胖症的超声波,肝酶 (ALT,AST/ALT比率) 和非酒精性脂肪肝纤维化评分 (NFS).
- 使用了对共变量调整后的物流回归分析.
主要成果:
- 减少MFRz-score与3.8倍增加的超声波肝硬化症的几率有关.
- 最强的相关性:男孩的MFRz-score与AST/ALT比 (r=0.530);女孩的脂肪百分比与NFS (r=0.503).
- 患有肝硬化症的儿童表现出更高的脂肪质量,更低的MFRz-score,以及增加的胰岛素耐药性和动脉脂失调症.
结论:
- 身体组成和肝纤维化标志物之间的关系存在显著的性别差异.
- 不良的身体成分与这种儿科队列中肝硬化症的可能性更高有关.
- 对身体成分的评估对于识别有肝病风险的儿童至关重要.
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