患者报告和临床医生评估的毒性与晚期癌症患者接受全身治疗的老年人日常功能之间的关系
Eva Culakova1, Mostafa Mohamed2,3, Marie Flannery3
1Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, New York, USA.
Cancer
|February 13, 2025
概括
患者报告的毒性,而不是临床医生评估的毒性,显著预测晚期癌症的老年人功能衰退. 评估两者对于管理治疗副作用和维持患者功能至关重要.
科学领域:
- 老年瘤学 老年瘤学
- 癌症治疗副作用 癌症治疗副作用
- 功能性成果研究研究结果
背景情况:
- 患有晚期癌症的老年人面临治疗相关毒性的风险增加.
- 这些毒性会显著损害身体和日常功能.
- 临床医生评估与患者报告的毒性和功能衰退之间的联系尚不清楚.
研究的目的:
- 调查临床医生评级 (CTCAE) 和患者报告 (PRO-CTCAE) 毒性与接受全身治疗的老年人功能衰退之间的关联.
- 为了区分临床医生评级与患者报告的毒性对身体表现和日常活动的影响.
主要方法:
- 对GAP70+试验数据的二次分析.
- 临床医生评估 (CTCAE) 和患者报告 (PRO-CTCAE) 的毒性.
- 评估身体表现 (短期身体表现电池 - SPPB) 和功能能力 (日常生活活动 - ADL,仪器ADL - IADL).
- 使用概括估计方程来分析毒性等级与新功能障碍之间的关联.
主要成果:
- 患者报告的更高的毒性严重程度和干扰 (PRO-CTCAE) 与新的身体性能障碍 (SPPB) 有关.
- 临床医生评级 (CTCAE) 和患者报告 (PRO-CTCAE) 毒性都与新的IADL损伤有关.
- 在临床医生评级的毒性 (CTCAE) 和新的SPPB损伤之间没有发现显著的关联.
结论:
- 患者报告的毒性是癌症老年人功能衰退的关键指标.
- 临床医生评估的毒性也起着作用,特别是在仪器ADL损伤中.
- 对临床医生评级和患者报告的毒性进行全面评估对于有效管理功能衰退至关重要.
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