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Updated: May 28, 2025

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科希斯H3 E97K突变促进了CENP-A错位化和染色体不稳定性在芽的酵母菌中

Kentaro Ohkuni1, Wei-Chun Au1, Amira Z Kazi1

  • 1Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Nucleic acids research
|February 13, 2025
PubMed
概括

改变的组织素H3水平或突变,如H3 E97K,导致CENP-A (Cse4) 的错位化和染色体不稳定性 (CIN). 这将组织素H3调节与与癌症相关的CIN联系起来.

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