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Updated: May 28, 2025

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
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通过细胞周期的核组织的三维记忆

Shin Fujishiro1, Masaki Sasai1,2

  • 1Fukui Institute for Fundamental Chemistry, Kyoto University, Kyoto 606-8103, Japan.

The Journal of chemical physics
|February 13, 2025
PubMed
概括

细胞分裂的结构记忆指导了整个细胞周期的基因组组织. 这项研究模拟了人类基因组的动态,揭示了 mitoosis 期间染色体的定位如何影响随后的细胞周期中的领土分布.

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Interphase

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Distribution of Cytoplasmic Content

Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
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Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
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