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Updated: May 28, 2025

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一个半三明治Os(II) 葡萄糖合NHC复合物作为氨基酸聚合的调节器

Daniele Florio1, Alfonso Annunziata2, Valeria Panzetta3,4

  • 1IRCCS SYNLAB SDN, Via G., Ferraris 144, Naples 80146, Italy.

Inorganic chemistry
|February 13, 2025
PubMed
概括

一种新复合物,Os-Tolu,通过稳定α-螺旋结构,有效抑制NPM1的粉样聚合264-277. 这一发现表明奥斯剂在治疗神经退行性疾病中的潜在治疗应用.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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