Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Kaplan-Meier Approach01:24

Kaplan-Meier Approach

80
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
80

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

HTD1801 in Combination with Metformin for Type 2 Diabetes.

NEJM evidence·2026
Same author

Hepatic Effects, Potential Drug-Induced Liver Injury, and Other Liver Safety Considerations of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in the New Era of Expanding Non-oncology Indications: Literature Review and Expert Consensus.

Drug safety·2025
Same author

Evaluating the Efficacy of MamaLift Plus Digital Therapeutic Mobile App for Postpartum Depression (SuMMER): Randomized, Placebo-Controlled Pivotal Trial.

Journal of medical Internet research·2025
Same author

Appendicitis in pregnancy, higher rate of perforation compared to nonpregnant patients.

Case reports in perinatal medicine·2025
Same author

HTD1801 demonstrates promising potential for histologic improvements in metabolic dysfunction-associated steatohepatitis in both a preclinical and phase 2 study.

Clinical and molecular hepatology·2025
Same author

The Impact of Liver Graft Preservation Method on Longitudinal Gut Microbiome Changes Following Liver Transplant: A Proof-of-concept Study.

Journal of clinical and translational hepatology·2025

相关实验视频

Updated: May 28, 2025

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

5.8K

对MASH疗法的组织学终点的挑战:统计建模的练习

Amrik Shah1, Leigh MacConell2, Alexander Liberman2

  • 1Karma Statistics LLC, Skillman, New Jersey, USA.

Alimentary pharmacology & therapeutics
|February 13, 2025
PubMed
概括
此摘要是机器生成的。

在代谢功能障碍相关的脂肪肝炎 (MASH) 试验中,组织学评分的不精确性使真正的效果大小减弱约50%,影响临床益处评估和支持非侵入性生物标志物.

关键词:
马什 (MASH) 是一个非常重要的产品.纳什·纳什 (Nash Nash) 是一个名为纳什的城市.组织学 组织学与代谢功能障碍相关的脂肪肝炎.模拟建模的模型.没有酒精含量的型肝炎.模拟模拟是指一个模拟模拟.

更多相关视频

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

2.5K
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

2.5K

相关实验视频

Last Updated: May 28, 2025

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

5.8K
Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

2.5K
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
10:49

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

2.5K

科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 临床试验方法论 临床试验方法论
  • 生物统计学 生物统计学

背景情况:

  • 目前的非酒精性脂肪肝炎 (NASH) 试验终点依赖于肝活检组织学,该组织学具有显著的inter-/intra-reader变异性.
  • 这种变异性使试验结果的解释变得复杂,因为很少有研究使用这些终点证明了积极的结果.

研究的目的:

  • 统计评估不准确的组织学评分对NASH/MASH临床试验结果的影响.
  • 为了量化由得分变化引起的真实效应大小稀释.

主要方法:

  • 基于协议措施和评分灵敏度之间的关系的模拟kappa值.
  • 利用NASH试验中公布的卡帕值来确定组织学参数灵敏度.
  • 进行了模拟,使用不同的过分/低分概率来估计效果大小稀释.

主要成果:

  • 模拟表明,在2臂试验中,纤维化改善和MASH分辨率终点的真实效果大小大约减小了50%.
  • 观察到这种稀释效应是不变的,无论试验的样本大小如何.

结论:

  • 不准确的组织学评分在临床试验中不成比例地影响"上层"臂.
  • 观察到的稀释需要在MASH研究的风险益处评估中加以考虑.
  • 这些发现支持采用非侵入性生物标志物,而不是传统的组织学终点.