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Updated: May 28, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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一种含有基因编码双二胺连接体的人工铜-米歇尔酶,用于对基酸盐进行不对称的添加

Ru Jiang1, Fabrizio Casilli1, Andy-Mark W H Thunnissen2

  • 1Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 3, 9747 AG, Groningen, The Netherlands.

Angewandte Chemie (International ed. in English)
|February 13, 2025
PubMed
概括

研究人员使用非正规氨基酸开发了一种新的铜人工金属酶 (ArM). 这种工程 Cu_Michaelase 能够通过新的生物催化转化,高效,对有价值的制药前体进行酶选择性合成.

关键词:
迈克尔的添加 迈克尔的添加人造金属酶是一种人造金属酶.指导进化是指导进化的.这种酸的酸.非正规的氨基酸.

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