冷暴露疗法增强单原子纳米酶介导的癌症疫苗疗法
Jinjun Ye1,2, Hongwei Wang1, Jingzhi Zheng3
1Department of General Surgery, Longgang Central Hospital of Shenzhen, Shenzhen 518100, China.
ACS applied materials & interfaces
|February 13, 2025
概括
这项研究开发了个性化的瘤疫苗,使用铜单原子纳米酶与冷暴露治疗相结合. 这种组合通过调节瘤微环境,显著提高了长期抗瘤疗效.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 单原子纳米酶 (SAZs) 由于高过氧化酶活性和生物相容性,对瘤疫苗 (TV) 有希望.
- 瘤免疫抑制限制了当前电视治疗的有效性.
- 冷暴露 (CE) 疗法提供了一种非侵入性的方法来抑制瘤并改善瘤微环境.
研究的目的:
- 使用铜单原子纳米酶 (Cu SAZ) 开发个性化的瘤疫苗 (TV).
- 通过整合冷暴露 (CE) 疗法来增强基于Cu SAZ的TV的长期抗瘤疗效.
主要方法:
- 铜单原子纳米酶 (CuSAZ) 是通过高温碳化合成的.
- SAZ表现出强烈的过氧化酶 (POD) 活性和光热特性,用于激光诱导的ROS和热量产生.
- 在体内瘤模型被用于评估Cu SAZ-TV与CE结合的疗效.
主要成果:
- SAZ表现出强大的POD活性和光热特性,诱导免疫细胞死亡并促进电视制作.
- 暴露在寒冷中显著提高了基于Cu SAZ的TV in vivo的抗瘤疗效.
- 脑电阻疗法降低了骨髓衍生抑制细胞 (MDSC) 和瘤细胞葡萄糖代谢,同时增加了CD8+ T细胞和记忆T细胞.
结论:
- 基于Cu SAZ的TV和CE疗法的组合提供了一种有希望的策略,用于增强长期抗瘤效果.
- 脑电阻疗法有效地重编程瘤微环境,克服免疫抑制并提高疫苗的疗效.
- 这种方法为开发先进和个性化的癌症疫苗提供了一个新的平台.
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