在患有囊性纤维化的婴儿中,肠道微生物群发育的持续延迟成熟
Adrian J Verster1, Paige Salerno1, Rebecca Valls1
1Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
mBio
|February 13, 2025
概括
患有囊性纤维化 (CF) 的婴儿表现出肠道微生物组成熟的延迟,有益细菌较少,口腔微生物更多. 这种与抗生素相关的发展变化可能可以通过向治疗来治疗.
科学领域:
- 微生物组研究的研究.
- 儿科卫生保健 儿科卫生保健
- 胃肠病学 胃肠病学
背景情况:
- 婴儿的肠道微生物从出生到3岁之间显著发展.
- 改变的肠道微生物群与成人疾病有关,但对儿科疾病的影响不太了解.
- 囊性纤维化 (CF) 与肠道微生物群组成的改变有关.
研究的目的:
- 在CF和非CF队列中概述婴儿肠道微生物群的菌株水平组成和发育动态.
- 在生命早期确定关键的微生物物种和发育模式.
- 了解CF如何影响微生物组成熟及其与临床因素的关联.
主要方法:
- 从CF和非CF婴儿 (出生至>36个月) 的便样本的纵向猎枪元基因组分析.
- 分析微生物的分类构成,发育轨迹和菌株级别动态.
- 微生物组特征与抗生素暴露和其他临床数据的相关性.
主要成果:
- 确定了定义非CF婴儿早期生命微生物群的基石物种;这些在CF婴儿中减少.
- 在CF婴儿中观察到微生物组成熟的延迟,持续的过渡状态和未能达到成人类稳定性.
- 在CF婴儿中发现口服细菌和真菌的相对丰度增加,与抗生素使用和细菌密度较低有关.
结论:
- 与健康婴儿相比,CF婴儿表现出延迟和改变的肠道微生物成熟模式.
- 暴露于抗生素显著导致CF的延迟成熟.
- 研究结果表明,针对微生物群的治疗有可能恢复CF的婴儿的健康肠道发育.
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