夜间高血压在患有与代谢功能障碍相关的脂肪性肝病的患者中构成一种不受控制的负担
Anna Martin1, Sonja Lang1, Felix Schifferdecker1
1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Gastroenterology and Hepatology.
Journal of hypertension
|February 13, 2025
概括
夜间高血压 (NH) 影响了超过一半的代谢功能障碍相关的脂肪性肝病 (MASLD) 患者. 关键的风险因素包括2型糖尿病,脂质失调和肝硬度增加,需要24小时的门诊血压监测来评估心血管风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是心血管疾病发病率和死亡率的重要危险因素.
- 动脉高血压 (AH) 也是MASLD患者的一个关键风险因素,估计患病率为50%.
- 24小时的门诊血压监测 (24-h-ABPM) 对于诊断高血压及其亚型至关重要,如夜间高血压 (NH),这是一个强大的心血管风险预测器.
研究的目的:
- 确定MASLD患者夜间高血压 (NH) 的患病率.
- 在这个患者群体中识别NH的相关风险因素.
主要方法:
- 预计招募226名有或没有已知的AH的MASLD患者.
- 执行24小时ABPM和重复的办公室血压测量.
- 在最终分析中包括218名患者的24小时ABPM数据.
主要成果:
- 在51.3%的分析MASLD患者中检测到夜间高血压 (NH).
- 在NH患者中,48.2%的患者尽管接受了抗高血压治疗,但仍患有无法控制的高血压.
- 独立的NH风险因素包括2型糖尿病 (T2DM),失脂症和肝硬度增加.
结论:
- 患有同时存在T2DM,脱脂症和肝硬度升高的MASLD患者表现出NH的高患病率.
- 这些患者患有心血管不良事件的风险增加.
- 常规的24小时ABPM建议在高危MASLD患者中早期检测和管理NH.
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