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Updated: May 28, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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使用HematoMap解决白血病异质性和血统异常问题

Yuting Dai1, Wen Ouyang1, Wen Jin1,2

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Genomics, proteomics & bioinformatics
|February 13, 2025
PubMed
概括

这项研究使用单细胞测序将白血病细胞映射到正常的血细胞发育. 该HematoMap工具有助于识别急性髓性白血病和B细胞前体急性淋巴细胞白血病的血统异常,以更好地分层风险.

关键词:
患有急性白血病的人.生物信息学是一种生物信息学.血液构成层次结构 血液构成层次结构血统偏差的偏差是一个问题.单细胞RNA测序的一个细胞.

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Commitment is the  process whereby stem cells:
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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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