孕激素主导的卵巢刺激 (PPOS) 在植入前遗传测试中检测动脉积分症:一项回顾性研究和元分析
Xi Qin1,2,3,4, Li Fan2,3,4, Yuxing Luo1
1Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Archives of gynecology and obstetrics
|February 13, 2025
概括
孕激素培养卵巢刺激 (PPOS) 协议显示胚胎欧状况和怀孕结果与植入前遗传测试 (PGT-A) 周期中的其他方法相比,具有可比性. 这表明PPOS是PGT-A的可行选择,需要进一步研究.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
- 遗传学 是一个遗传学.
背景情况:
- 有限的数据存在于孕激素原始卵巢刺激 (PPOS) 协议对胚胎欧状况和前植入基因测试对阳 (PGT-A) 结果的影响.
- 本研究评估了PPOS协议在PGT-A周期中的有效性,与其他刺激方法相比.
研究的目的:
- 评估PPOS协议在PGT-A周期中的应用价值.
- 为了比较PPOS与淋巴激素释放激素抗剂 (GnRH-ant) 和GnRH激动剂 (GnRH-a) 关于胚胎和怀孕结果的协议.
主要方法:
- 一项对962个卵巢刺激周期 (PPOS,GnRH-ant,GnRH-a) 的回顾性队列研究.
- 一个元分析搜索多个数据库 (PubMed,Embase等). 和临床试验登记册.
- 对胚胎和怀孕结果的分析,考虑基线特征平衡.
主要成果:
- 与GnRH-a相比,PPOS和GnRH-ant协议与老年患者和卵巢储备标志物降低有关.
- 卵巢刺激方案没有显著影响euploid胚胎细胞的数量或每次活检的速度.
- 在这三个组之间,怀孕和活产率没有显著差异;在元分析中,PPOS显示堕胎率显著下降.
结论:
- 该PPOS协议表明胚胎euploid状态和怀孕结果与其他刺激协议在PGT-A周期中相似.
- PPOS可能是PGT-A的一个有吸引力的选择,需要通过精心设计的RCT和长期随访来验证.
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