宫脊髓炎的液体生物标志物宫脊髓炎骨髓病
Michael R Kann1, Raj Swaroop Lavadi1, Alex Crane1
1Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Neurosurgical review
|February 13, 2025
概括
这次审查发现了液体生物标志物和椎脊髓炎 (CSM) 之间的关联. 需要更多的研究来了解这些生物标志物,如NSE,S100b和pNF-H,如何帮助评估CSM患者.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物研究 生物标志物研究
- 脊髓医学 脊髓医学
背景情况:
- 有限的文献存在于椎脊髓炎 (CSM) 的基于液体的生物标志物.
- 了解这些生物标志物对于了解CSM症状表现和恢复至关重要.
- 本综述综合了关于CSM中侵入性,基于液体的生物标志物的当前知识.
研究的目的:
- 系统地审查和综合关于椎脊髓炎 (CSM) 的基于液体的生物标志物的文献.
- 评估这些生物标志物在CSM中的临床意义.
- 确定目前关于CSM生物标志物的研究中的差距.
主要方法:
- 对生物标志物和CSM进行了全面的文献搜索.
- 纳入标准侧重于涉及CSM的动物或人类受试者的原始研究.
- 偏差风险使用OHAT偏差风险评级工具进行评估.
主要成果:
- 20项研究符合191个独特手稿的纳入标准.
- 评估的液体生物标志物包括血液和脑脊液 (CSF).
- 常见的生物标志物是NSE,S100b和pNF-H,在研究中注意到一些偏差风险.
结论:
- 血液/CSF生物标志物和CSM之间存在关联.
- 研究中的异质性限制了最终的结论.
- 需要进行更大规模的前性研究,以澄清CSM临床评估中的生物标志物的实用性.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
43
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
43
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
86
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
86