在45岁以下的成年人中预测先进结肠直肠瘤的得分
Sarah Wehbe1, Raj Jessica Thomas2, Jacquelyn Bolwell1
1Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Digestive diseases and sciences
|February 13, 2025
概括
一个新的风险评分确定了年轻的成年人在45岁之前患有晚期结直肠瘤 (AN) 的高风险. 该工具使用BMI,家族史和烟草使用来预测AN的可能性,帮助个性化结直肠癌查.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 早发性结肠直肠癌 (CRC) 是一个日益关注的问题,需要识别45岁以下的风险人群.
- 在年轻人中检测先进瘤 (AN) 需要风险分层,以便及时进行结肠镜检查.
研究的目的:
- 在45岁以下的成年人中开发和验证先进结直肠瘤 (AN) 的预测模型.
- 在这个人口群体中确定与AN相关的关键临床风险因素.
主要方法:
- 对9446名年龄在18-44岁的成年人进行结肠镜检查 (2011-2021) 的横截面分析.
- 多变量逻辑回归用于在训练集上构建预测模型.
- 内部验证的模型,评估歧视力 (c-统计).
主要成果:
- 在3.7%的参与者中发现了高级瘤 (AN).
- 确定了关键预测因素:BMI,家族史CRC,以及烟草使用.
- 经验证的模型显示了适度的预测能力 (c-统计值0.645).
结论:
- 一个简单的临床风险得分有效地预测了45岁以下成年人AN的可能性.
- 该得分利用BMI,家族史和烟草使用.
- 在个性化结直肠癌查中潜在使用需要外部验证.
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