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在患有家族性炎症性肠病的患者中,患病率,临床特征和肠外表现
Christina Liava1, Danai Chourmouzi2, Emmanouil Sinakos3
1Fourth Department of Internal Medicine, Hippokration General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Konstantinoupoleos Str. 49, 54642, Thessaloniki, Greece. christinli@auth.gr.
炎症性肠道疾病 (IBD) 的家族史是常见的,特别是在克罗恩病中. 家族性IBD增加了住院,手术和并发症的风险,如围疾病和肠外表现.
科学领域:
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 积极的家族病史是炎症性肠道疾病 (IBD) 的重要风险因素,在8-12%的患者中发现.
- 了解家族性IBD对于风险评估和管理至关重要.
研究的目的:
- 为了确定家族性IBD的流行率.
- 为了比较家族和零星IBD病例之间的临床特征和肠外表现.
主要方法:
- 一项采用265名IBD患者 (年龄为16-90岁) 追溯前性收集数据的横截面研究.
- 包括经过活检确认的家族和零星IBD病例.
- 通过综合问卷收集的数据;使用后勤回归和千平方测试进行分析.
主要成果:
- 12.1%的IBD患者有IBD的一级亲属 (16.4%的克罗恩病,5.7%的性结肠炎).
- 亲属IBD患者更常见的是女性,被诊断患有克罗恩氏病,并且患有住院,手术,生物治疗,围疾病和肠外表现 (例如,关节并发症,红斑结节,脑膜炎) 的风险更高.
结论:
- 在16.4%的克罗恩氏病患者和5.7%的性结肠炎患者中存在IBD的阳性家族史.
- 家庭性IBD与住院,手术,近部疾病,生物疗法和肠外表现的风险增加有关.
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