Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Vision01:24

Vision

52.9K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
52.9K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

5.9K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
5.9K
Visual System01:26

Visual System

483
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
483

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma Pathophysiology.

Research square·2026
Same author

Meeting report for the Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026).

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

VTA dopamine inputs activate accumbal D1 receptors to promote alcohol seeking.

iScience·2026
Same author

CIPHER: An end-to-end framework for designing optimized aggregated spatial transcriptomics experiments.

PLoS computational biology·2026
Same author

Nmur1 and Cckar fail to support functional genetic access in adult dopamine neurons and challenge GPCR atlas assignments.

bioRxiv : the preprint server for biology·2026
Same author

Multi-Task Path-Based Heterogeneous Graph Model for Functional Brain Network Analysis and Gender-Related Diseases Diagnosis.

IEEE journal of biomedical and health informatics·2026

相关实验视频

Updated: May 28, 2025

Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.1K

视觉皮层中细胞类型和视觉依赖的转录学程序之间的相互作用的空间描述.

Fangming Xie1, Saumya Jain1,2, Runzhe Xu1

  • 1Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Proceedings of the National Academy of Sciences of the United States of America
|February 13, 2025
PubMed
概括
此摘要是机器生成的。

早期的视觉体验塑造了哺乳动物大脑中神经元如何组织. 视觉剥夺会改变2/3层 (L2/3) 细胞中的基因表达,影响它们在视觉皮层中的身份和空间分布.

关键词:
皮层 皮层 皮层梯度梯度的梯度是指梯度的梯度.空间转录学 空间转录学翻译学 翻译学 翻译学 翻译学视觉 视觉 视觉 视觉 视觉 是一个

更多相关视频

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K
Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells
11:26

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells

Published on: May 22, 2017

13.7K

相关实验视频

Last Updated: May 28, 2025

Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.1K
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K
Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells
11:26

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells

Published on: May 22, 2017

13.7K

科学领域:

  • 神经科学是一个神经科学.
  • 发育生物学 发展生物学
  • 基因组学就是基因组学.

背景情况:

  • 早期感官体验对细胞水平新皮质组织的影响尚不清楚.
  • 之前的研究表明,主要视觉皮层 (V1) 中2/3层 (L2/3) 细胞的功能和分子概况取决于视觉输入.
  • 了解关键时期的可塑性对于理解大脑发育至关重要.

研究的目的:

  • 研究V1中L2/3细胞类型的空间组织与视觉体验的关系.
  • 阐明视觉剥夺影响L2/3细胞类型的分子机制.
  • 绘制视觉在发育过程中对皮质细胞类型分布的影响.

主要方法:

  • 使用大约500个基因,对V1 L2/3细胞进行空间转录基因分析.
  • 在正常养和深色养小鼠之间的基因表达和空间组织的比较.
  • 空间转录学与单核RNA测序数据的整合.

主要成果:

  • 空间转录学揭示了L2/3细胞类型在V1.1中沿着平-心室轴的区分.
  • 视觉剥夺诱导了两个明显的转录变化:细胞状态转移 (与细胞身份直角) 和L2/3多重体内的细胞类型身份转移.
  • 第一个基因程序涉及直接早期的基因和代谢基因,而第二个影响细胞类型特定的基因.

结论:

  • 在关键发育时期,视觉体验是 L2/3 细胞类型和它们在 V1 中的空间组织模式的关键因素.
  • 多任务理论为理解L2/3细胞类型的连续基因表达特征和区分提供了一个框架.
  • 该研究揭示了不同的分子机制,通过视觉输入以细胞分辨率塑造皮质电路.