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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

633
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
633
T Cell Types and Functions01:24

T Cell Types and Functions

938
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
938

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相关实验视频

Updated: May 28, 2025

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

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代谢T细胞表型:从生物能学到功能

Nouria Jantz-Naeem1, Nese Guvencli2, Romy Böttcher-Loschinski2

  • 1Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

American journal of physiology. Cell physiology
|February 13, 2025
PubMed
概括

重编程T细胞代谢对于免疫反应至关重要. 了解T细胞中改变的代谢概况是开发针对各种疾病的个性化免疫疗法的关键.

关键词:
在T细胞,T细胞.自体免疫性是一种自身免疫性.癌症 癌症 癌症 癌症 癌症免疫代谢的免疫代谢.病毒感染 病毒感染

更多相关视频

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

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Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

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相关实验视频

Last Updated: May 28, 2025

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

187
Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

3.8K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞的新陈代谢
  • 系统生物学 系统生物学

背景情况:

  • T细胞的功能与其代谢状态密切相关.
  • 代谢重编程支持T细胞的能量需求和生物合成.
  • 功能障碍的T细胞代谢可以驱动疾病病理.

研究的目的:

  • 在不同疾病中审查T细胞子集的代谢变化.
  • 突出免疫代谢在T细胞生物能量学中的作用.
  • 在T细胞代谢中识别治疗点.

主要方法:

  • 关于免疫代谢研究的文献综述.
  • 分析T细胞子集的代谢变化.
  • 整合来自自身免疫,病毒和恶性疾病的数据.

主要成果:

  • 特定的T细胞子集表现出不同的代谢概况.
  • 代谢重编程在自身免疫性疾病,病毒感染和癌症中发生变化.
  • 异常的T细胞代谢会影响疾病的进展和免疫反应.

结论:

  • 了解T细胞代谢内型对个性化医学至关重要.
  • 针对免疫代谢提供了潜在的治疗策略.
  • 对T细胞生物能量的进一步研究可以促进免疫治疗.