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工作行为和感觉神经听力损失的风险:一项大型队列研究

Wendu Pang, Yao Song, Jun Xie

¹Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, China. yuzhao@wchscu.edu.cn.

Scandinavian journal of work, environment & health

|February 13, 2025

概括

轮班工作,夜班工作和体力苛刻的工作增加了感官神经听力损失 (SNHL) 的风险. 这些职业因素与更严重的双边SNHL有关,无论遗传倾向如何.

科学领域:

职业健康职业健康职业健康
听力学听力学是指听力学.
流行病学流行病学

背景情况:

感官神经听力损失 (SNHL) 是一个重大的公共卫生问题.
了解职业暴露对听力健康的影响至关重要.

研究的目的:

研究特定的工作行为与神经感官听力损失 (SNHL) 之间的关联.
分析有关SNHL发生,横向性和严重性的关系.

主要方法:

对大型队列进行了横截面和前性分析 (N=90,286和N=8,341).
评估的工作行为包括轮班工作,夜班工作和体力苛刻的工作.
使用了多变量回归模型,子组分析和多基因风险评分 (PRS).

主要成果:

轮班工作,夜班工作和体力苛刻的工作与SNHL风险增加有显著的关联 (P<0.05).
这些行为与更大的SNHL严重性和更高的双边SNHL可能性相关.
关联不论遗传易感性 (PRS) 存在还是存在,并且在特定的子组中表现明显.

结论:

职业轮班工作,夜班工作和体力苛刻的工作与SNHL的更高风险有关.
这些工作条件也增加了SNHL的严重性和双边性.
确定的关联是独立于个体对SNHL的遗传风险.

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相关概念视频

Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.