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在心房数字双胞胎中定义心肌纤维束架构

Roberto Piersanti¹, Ryan Bradley², Syed Yusuf Ali³

¹MOX - Laboratory of Modeling and Scientific Computing, Dipartimento di Matematica, Politecnico di Milano, Milano, Italy; ADVANCE - Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, USA.

Computers in biology and medicine

|February 13, 2025

概括

一种新方法准确地为数字双胞胎绘制了心房心肌纤维的地图,改进了电生理学模拟. 这为个性化医学推进了基于物理的虚拟心脏模型.

科学领域:

生物医学工程生物医学工程
计算生物学计算生物学
医疗成像医学成像

背景情况:

准确的心肌纤维方向对于患者特异性心房数字双胞胎 (ADT) 非常重要.
目前在ADT中生成心房纤维的方法通常依赖于缺乏验证的数学模型,并受到特定心房形态的限制.
从医学成像中直接重建心房纤维存在重大挑战.

研究的目的:

为ADT引入一种新的,可靠的方法,用于在复杂的双心房几何中规定详细的肌纤维方向和区域注释.
根据高分辨率的扩散电阻磁共振成像 (DTMRI) 数据验证拟议的方法.
在电生理学模拟中,将新方法的性能与现有的最先进的纤维模型进行比较.

主要方法:

开发心房拉普拉斯-迪里克莱特基于规则的方法 (LDRBM) 来生成肌纤维的方向.
使用从亚毫米DTMRI人类心房纤维数据集衍生出的八个详细的双心房几何学验证.
量化比较LDRBM产生的纤维与DTMRI基准真相,并评估由此产生的电生理学模拟差异.

主要成果:

在LDRBM成功地重建了DTMRI纤维架构,在多样化和复杂的双心房形态学中具有高保真性.
使用LDRBM规定的纤维的电生理学模拟与使用其他模型的模拟相比,显示出更好的准确性.
该LDRBM表现出优越的性能比现有的方法,包括通用心房坐标.

结论:

LDRBM提供了一种强大而准确的方法,用于在ADT中规定详细的肌纤维方向,其性能优于当前最先进的方法.
准确的纤维定向处方对于ADT内的可靠电生理学模拟至关重要.
这项工作为ADT中的纤维建模建立了新的标准,为基于物理的先进数字双胞胎的人类心房铺平了道路.

关键词:

心脏数字双胞胎是什么意思心脏纤维架构的心脏纤维结构计算建模计算建模数字模拟的数字模拟.精准医学是一门精准的医学.

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