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使用基于液态染色学的方法对mRNA关键质量属性的表征和分析

Alexandra L J Webb1, Emma N Welbourne1, Caroline A Evans1

  • 1School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, S1 3JD, UK.

Journal of chromatography. A
|February 13, 2025
PubMed
概括

使者RNA (mRNA) 分析对于开发超越疫苗的新疗法至关重要. 本综述详细介绍了用于表征mRNA关键质量属性的高性能液态色谱方法.

关键词:
关键的质量属性是关键的质量属性.在HPLC中使用HPLC.质谱测量质量谱测量它们是mRNARNA.mRNA 疫苗/治疗药物

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Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
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