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相关概念视频

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicokinetics: Overview01:21

Toxicokinetics: Overview

Studies that assess how a drug is absorbed, distributed, metabolized, and excreted (ADME) at toxic doses are termed toxicokinetics. Understanding toxicokinetics helps predict adverse drug reactions (ADRs) and manage toxicity in humans.Toxicokinetics differs from pharmacokinetics mainly in the dose levels studied, with toxicokinetics focusing on higher toxic doses. The kinetics at these levels can be non-linear due to altered physiological processes. Toxicodynamics examines the relationship...
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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捕捉水生生态毒理学风险的时间变化:基于化学与效应的评估.

H Boonstra1, M L de Baat2, F van der Meer3

  • 1Wetterskip Fryslân, 8914, BZ, Leeuwarden, the Netherlands; Department of Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, 1098, XH, Amsterdam, the Netherlands.

The Science of the total environment
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概括

基于效果的方法与被动采样相结合,可以比单独的化学分析更好地捕捉水生生态毒理学风险的时间变化. 未被检测到的化学物质在很大程度上推动了农业水道的毒性,需要先进的分析来进行全面的风险评估.

关键词:
生物测试电池电池的使用方法基于效果的方法 基于效果的方法杀菌剂是一种杀菌剂.混合物的毒性 混合物的毒性被动抽样是一种被动抽样.季节性变化季节性变化

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科学领域:

  • 环境化学环境化学
  • 生态毒理学 生态毒理学
  • 分析化学 分析化学

背景情况:

  • 评估水生生态系统中化学混合物的生态毒理风险需要基于效应的综合化和化学分析.
  • 污染物度的时间和空间变化给准确的风险评估带来了挑战.

研究的目的:

  • 评估组合的被动采样,基于效果的和化学分析的能力,以捕捉水生生态毒理学风险的时间变化.
  • 通过综合采样和分析技术,评估农业水道中的生态毒理风险.

主要方法:

  • 在四个连续的六周期间,在农业水道中使用皮纸和极地有机化学集成样本 (POCIS) 进行被动时间集成采样.
  • 使用22个体外和体内生物测试和225个化合物的目标分析分析样本提取物.
  • 评估生物测试反应和化学度的时间和空间变化.

主要成果:

  • 波动的生物测试反应表明,在所有地点和采样期间,有毒压力存在时间和空间的变化.
  • 杀菌剂和除草剂被始终检测到,但在不同的度,表明持久但动态的化学压力.
  • 检测到的化学物质只解释了观察到的毒性的一小部分 (1-16.9%),这表明未检测到的污染物占主导地位.

结论:

  • 与被动采样相结合的基于效应的评估优于传统的化学分析,用于捕捉生态毒理学风险的时间变化.
  • 农业水道中毒性的很大一部分是由于未被检测到的化学物质造成的,这凸显了对先进分析方法的需求.
  • 风险评估揭示了基于效应的触发值的频繁超越,强调了这些环境中潜在的生态毒理风险.