人类骨组织中的微塑料:存在,分布和健康影响
Qiaoyi Yang1, Ye Peng2, Xiaodong Wu3
1Department of Health Education and Management and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Environment international
|February 13, 2025
概括
在人类的骨,软骨和椎间盘中发现了微塑料,它们在各个组织中以不同的方式积累. 这项研究揭示了微塑料入侵通过改变炎症标志物和骨代谢而影响骨健康.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 人体生理学 人体生理学
背景情况:
- 微塑料是无处不在的环境污染物.
- 之前的研究已经在人体血液和胎盘中检测到微塑料.
- 微塑料对人类骨组织的存在和影响在很大程度上仍未被描述.
研究的目的:
- 描述人类骨,软骨和椎间盘中的微塑料沉积模式.
- 研究微塑料对骨组织的侵入途径和潜在的健康影响.
主要方法:
- 在24个人类骨组织样本 (骨,软骨,椎间盘) 中分析了40个微塑料碎片.
- 微塑料的数量和大小分布的量化.
- 在体内实验中,通过血液循环追踪微塑料的入侵.
- 测量血清炎症标记物 (TNF-α) 和骨代谢标记物 (PINP,TRACP-5b).
主要成果:
- 在所有三种骨组织类型中都检测到微塑料,在椎间盘中更丰富.
- 与软骨相比,椎间盘和骨的平均微塑料大小较大.
- 聚烯,乙烯乙酸共聚合物和聚烯是最常见的聚合物.
- 在体内暴露导致微塑料在4周内侵入骨组织.
- 暴露后观察到TNF-α,PINP和TRACP-5b的血清水平升高.
结论:
- 微塑料可以通过血液循环侵入人类的骨,软骨和椎间盘.
- 在不同的骨组织中存在不同的微塑料积累模式.
- 微塑料暴露可能通过影响炎症和骨重塑过程对骨健康产生负面影响.
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